Optical-Tweezers-Based Microrheology of Soft Materials and Living Cells

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Abstract

Optical tweezers [1] use a highly focused laser beam to form a stable trap to confine one or more micron- or nano-sized particles in three-dimensional space, enabling noninvasive manipulation, without any mechanical contact, of microscopic probe particles embedded in a sample. Since its first demonstration in 1986 by Ashkin et al. [2], single-beam optical tweezers have been used to manipulate microscopic objects such as colloidal particles [3], biomolecules [4, 5], and biological cells [6–9]. In addition, optical tweezers have also been used as pico-Newton force transducers to measure the strength of molecular bonds [10] and to determine the transmission of forces in the microscopic environment of complex fluids [11–14]. Combining the ability to manipulate microparticles with force measurement, optical tweezers have been used to study the micromechanical properties of soft materials [15, 16], such as colloidal crystals [17–20], liquid crystals [21–23], carbon nanotube suspensions [24], actin-coated lipid vesicles [25–27], living cells [28–33], cytoskeletal networks [34–37], DNA networks [38, 39], polymer solutions [40–42], collagen gels [43, 44], human erythrocyte membranes [45–49], and even individual strands of DNA molecules [5, 50].

Keywords

Optical Tweezer Viscoelastic Medium Probe Particle Optical Force Complex Shear Modulus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  • Ming-Tzo Wei
    • 1
  • Olga Latinovic
    • 2
  • Lawrence A. Hough
    • 3
  • Yin-Quan Chen
    • 4
  • H. Daniel Ou-Yang
    • 1
    • 5
  • Arthur Chiou
    • 4
    • 6
  1. 1.Bioengineering ProgramLehigh UniversityBethlehemUSA
  2. 2.Institute of Human VirologyUniversity of Maryland School of MedicineBaltimoreUSA
  3. 3.Complex Assemblies of Soft Matter LabUMI 3254 CNRS/UPENN/RhodiaBristolUSA
  4. 4.Institute of BiophotonicsNational Yang-Ming UniversityTaipeiTaiwan
  5. 5.Department of PhysicsLehigh UniversityBethlehemUSA
  6. 6.Biophotonics and Molecular Imaging Research CenterNational Yang-Ming UniversityTaipeiTaiwan

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