Cerebellar Development and Neurogenesis in Zebrafish

Reference work entry

Introduction

Cerebellar organization and function have been studied in numerous species of fish. Fish models such as goldfish and weakly electric fish have led to important findings about the cerebellar architecture, cerebellar circuit physiology, and brain evolution. However, most of the studied fish models are not well suited for developmental and genetic studies of the cerebellum. The rapid transparent ex uterodevelopment in zebrafish allows direct access and precise visualization of all the major events in cerebellar development. The superficial position of the cerebellar primordium and cerebellum further facilitates in vivo imaging of cerebellar structures and developmental events. Furthermore, zebrafish is amenable to high-throughput screening techniques and forward genetics because of its fecundity and easy keeping. Forward genetics screens in zebrafish have resulted in several isolated cerebellar mutants and substantially contributed to the understanding of the genetic...

Keywords

Granule Cell Granule Cell Layer Purkinje Neuron Ventricular Zone Deep Cerebellar Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Developmental Genetics, Biotechnology Center and Center for Regenerative Therapies DresdenDresden University of TechnologyDresdenGermany
  2. 2.Australian Regenerative Medicine Institute (ARMI)Monash UniversityMelbourneAustralia

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