Punctate Inner Choroidopathy (PIC)
Punctate inner choroidopathy (PIC) is mostly a bilateral, multifocal chorioretinopathy which affects predominantly young myopic Caucasian women. Characteristic fundus lesions are small, well-demarcated yellow-gray chorioretinal lesions (100–300 μm) mostly limited to the posterior pole at the level of retinal pigment epithelium (RPE) and inner choroid. Choroidal neovascularization (CNV) and subretinal fibrosis are the two sight-threatening complications associated with punctate inner choroidopathy. Treatment varies from observation (if the disease is stable without progression) to immunomodulatory therapy (IMT) and/or anti-VEGF therapy based on the extent, recurrences of activity, and associated complications.
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