Collectin is a very unique protein, which has two characteristic domains: a collagen-like sequence and carbohydrate recognition domain (CRD). It is considered as a receptor recognizing a pathogen with associated molecular patterns (PAMPs) that play an important role in innate immunity. Recently, it was demonstrated that several collectins can not only activate the complement pathway but are also involved in various biological functions different from a host defense. In this chapter, we focus on “complement activation-related collectins,” consisting of mannan-binding lectin (MBL), complement 1q (C1q), collectin kidney 1 (CL-K1), and collectin placenta 1 (CL-P1), and summarize and discuss various new aspects of their functions.
This is a preview of subscription content, log in to check access
Agostinis C, Bulla R, Tripodo C et al (2010) An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development. J Immunol 185:4420–4419CrossRefPubMedGoogle Scholar
Aramini B, Kim C, DiAngelo S et al (2013) Donor surfactant protein D (SP-D) polymorphisms are associated with lung transplant outcome. Am J Transplant 13:2130–2136CrossRefPubMedGoogle Scholar
Fukuda M, Ohtani K, Jang S-J et al (2011) Molecular cloning and functional analysis of scavenger receptor zebrafish CL-P1. Biochim Biophys Acta 1810:1150–1159CrossRefPubMedGoogle Scholar
Job ER, Deng YM, Tate MD et al (2010) Pandemic H1N1 influenza A viruses are resistant to the antiviral activities of innate immune proteins of the collectin and pentraxin superfamilies. J Immunol 185:4284–4291CrossRefPubMedGoogle Scholar
Ling MT, Tu W, Han Y et al (2012) Mannose-binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection. J Infect Dis 205:44–53CrossRefPubMedPubMedCentralGoogle Scholar
Munster JM, van der Bij W, Breukink MB et al (2008) Association between donor MBL promoter haplotype and graft survival and the development of BOS after lung transplantation. Transplantation 86:1857–1863CrossRefPubMedGoogle Scholar