FGF System and GAGs

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Abstract

In the fibroblast growth factor (FGF) system, sulfated glycosaminoglycans (GAGs) play very important roles. They interact with most FGF ligands and their receptors (FGFRs) and enable formation of active and stable signaling complexes composed of FGF-FGFR or FGF-FGFR/coreceptor. The fine structures of GAGs, particularly position-specific O-sulfation patterns, determine the GAGs’ regulatory activity toward specific FGFs and FGFRs.

Keywords

(FGF) β-Klotho Chondroitin sulfate FGF receptors GAGs Glycosaminoglycans Heparan sulfate Heparin Klotho O-sulfation 
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Copyright information

© Springer Japan 2015

Authors and Affiliations

  1. 1.Signaling Molecules Research Group, Biomedical Research InstituteNational Institute of Advanced Industrial Science and Technology (AIST)TsukubaJapan
  2. 2.Cell Regulation Laboratory, School of Bioscience and BiotechnologyTokyo University of TechnologyHachiojiJapan

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