Compendium of Inflammatory Diseases

2016 Edition
| Editors: Michael J. Parnham

Interleukin 36 Cytokines

Reference work entry
First Online:
DOI: https://doi.org/10.1007/978-3-7643-8550-7_216
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Synonyms

FIL1delta; FIL1epsilon; FIL1eta; IL-1F5; IL-1F6; IL-1F8; IL-1F9; IL-1H1; IL-1H2; IL-1H3; IL1HY1; IL-1L1; IL-1RP2; IL-1RP3; IL-36α; IL-36β; IL-36γ

Definition

Several new members of the IL-1 gene family have been discovered over the last decade. Novel cytokines, such as IL-36 cytokines, were renamed in order of their date of publication (Sims et al. 2001). It was proposed in 2010 that these IL-1 family members should each be assigned an individual interleukin designation based on their biological function (Dinarello et al. 2010). The cytokines that were renamed IL-36α, IL-36β, IL-36γ, and IL-36 receptor antagonist (Ra) are collectively called the IL-36 cytokines (Table 1).
Interleukin 36 Cytokines, Table 1

IL-36 cytokines

 

New nomenclature

Alternative names

Signaling

Homology

Processing for optimal bioactivity

Expression

Induction

IL-1Ra (%)

IL-1β (%)

IL-36 cytokines

IL-36Ra

IL-1F5, IL1HY1, IL-1L1, IL-1RP3, IL-1H3, FIL1delta

Binds IL-1Rrp2 and blocks IL-1racp recruitment

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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  1. 1.Department of Internal MedicineRadboud University Nijmegen Medical CentreGAThe Netherlands
  2. 2.Department of MedicineUniversity of Colorado DenverAuroraUSA