Compendium of Inflammatory Diseases

2016 Edition
| Editors: Michael J. Parnham

Lymphocyte Homing and Trafficking

Reference work entry
First Online:
DOI: https://doi.org/10.1007/978-3-7643-8550-7_130
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Synonyms

Lymphocyte migration

Definition

Lymphocytes are central effector cells of adaptive immune responses. Their ability to migrate from one place to another is a major feature of their action since the initiation of immune responses is centralized in secondary lymphoid organs while the effector phase takes place where needed in peripheral tissues. Here the mechanisms responsible for this ability and major trafficking pathways of lymphocyte in normal and pathological conditions will be discussed.

Structure and Functions

Molecular Basis of Lymphocyte Trafficking

Lymphocyte homing and trafficking are essential functions of adaptive immune responses. The basic molecular processes involved in trafficking are chemotaxis and cellular adhesion. Chemotaxis is mediated mainly by chemokines and inflammatory response by-products (anaphylatoxins and prostaglandins), while cellular adhesion is mediated by selectins interacting with sugars (weak interactions) and integrins (strong interactions).

Chemotaxis...

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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  1. 1.INSERM UMRS 996Universté Paris SudChatenay-MalabryFrance