Vaginal Secretions with Age

Reference work entry

Abstract

Vaginal secretions are influenced by the dynamics of female hormones as well as local pathology. As an intended defense against infection, secretions contain innate “natural antibiotic” chemicals that at least regulate normal vaginal flora. Anaerobic metabolism of glucose into lactate by the genital tract epithelium as well as anaerobic or facultative microbes maintains a mildly acidic pH that is important for normal skin metabolism. Characteristic changes in the exfoliated epithelial content of vaginal secretions can indicate local inflammatory skin disorders such as mucus membrane graft vs host disease, lichen planus, lichen simplex, or lichen sclerosus.

Keywords

Vaginal secretions Vaginal pH Innate vaginal immunity Vaginal dermatopathology Lactobacillus 

References

  1. 1.
    Burgos MH. Roig de vargas-Linares CE. Cell junctions in the human vaginal epithelium. Am J Obstet Gynecol. 1970;108(4):565–7.CrossRefPubMedGoogle Scholar
  2. 2.
    Wagner G, Levin RJ. Vaginal fluid. In: Hafez ESE, Evans TN, editors. The human vagina. New York: North-Holland; 1978. p. 123.Google Scholar
  3. 3.
    Zhou X, Bent SJ, Schneider MG, et al. Characterization of vaginal microbial communities in adult healthy women using cultivation-independent methods. Microbiology. 2004;150:2565–73.CrossRefPubMedGoogle Scholar
  4. 4.
    Zhou X, Brown CJ, Abdo Z, et al. Differences in the composition of vaginal microbial communities found in healthy Caucasian and black women. ISME J. 2007;1:121–33.CrossRefPubMedGoogle Scholar
  5. 5.
    Huggins GR, Preti G. Volatile constituents of human vaginal secretions. Am J Obstet Gynecol. 1976; 126(1):129–36.CrossRefPubMedGoogle Scholar
  6. 6.
    Cauci S, Hitti J, Noonan C, Agnew K, Quadrifoglio F, Hillier SL, Eschenbach DA. Vaginal hydrolytic enzymes, immunoglobulin against Gardnerella vaginalis toxin, and early risk of preterm birth among women in preterm labor with bacterial vaginosis or intermediate flora. Am J Obstet Gynecol. 2002; 187:877–81.CrossRefPubMedGoogle Scholar
  7. 7.
    Preti G, Huggins GR. Cyclical changes in volatile acidic metabolites of human vaginal secretions and their relation to ovulation. J Chem Ecol. 1975; 1:361–76.CrossRefGoogle Scholar
  8. 8.
    Preti G, Hugins GR. Organic constituents of vaginal secretions. In: Hafez ESE, Evans TN, editors. The human vagina. New York: North-Holland; 1978. p. 162–3.Google Scholar
  9. 9.
    Gross M. Biochemical changes in the reproductive cycle. Fertil Steril. 1961;12(3):245–62.CrossRefPubMedGoogle Scholar
  10. 10.
    Society of Obstetricians and Gynecologists of Canada. The detection and management of vaginal atrophy. Int J Gynecol Obstet. 2004;88:222–8.Google Scholar
  11. 11.
    Weinstein L, Howard JH. The effect of estrogenic hormone on the H-ion concentration and the bacterial content of the human vagina with special reference to the Doederline bacillus. Am J Obstet Gynecol. 1939; 37:698–703.CrossRefGoogle Scholar
  12. 12.
    Weinstein L, Bogin M, Howard JH, Finkelstone BB. A survey of the vaginal flora at various ages with special reference to the Doederline bacillus. Am J Obstet Gynecol. 1936;32:211–8.CrossRefGoogle Scholar
  13. 13.
    Raskoff AE, Feo LG, Goldstein L. The biologic characteristics of the normal vagina. Am J Obstet Gynecol. 1943;47:467–94.CrossRefGoogle Scholar
  14. 14.
    Tsai CC, Semmens JP, Semmens EC, Lam CF, Lee FS. Vaginal physiology in postmenopausal women: pH value, transvaginal electropotential difference, and estimated blood flow. South Med J. 1987;80:987–90.CrossRefPubMedGoogle Scholar
  15. 15.
    Gorodeski GI, Hopfer U, Liu CC, Margles E. Estrogen acidifies vaginal pH by up-regulation of proton secretion via the apical membrane of vaginal-ectocervical epithelial cells. Endocrinology. 2005;146(2):816–24.CrossRefPubMedGoogle Scholar
  16. 16.
    Bo WJ. The effect of progesterone and progesterone-estrogen on the glycogen deposition in the vagina of the squirrel monkey. Am J Obstet Gynecol. 1970; 107:524–30.PubMedGoogle Scholar
  17. 17.
    Ayre WB. The glycogen-estrogen relationship in the vaginal tract. J Clin Endocrinol Metab. 1951; 11:103–10.CrossRefPubMedGoogle Scholar
  18. 18.
    Weisberg E, Aytin R, Darling G, et al. Endometrial and vaginal effects of dose-related estradiol delivered by vaginal ring or vaginal tablet. Climacteric. 2005; 8:83–92.CrossRefPubMedGoogle Scholar
  19. 19.
    Kunin CM, Evans C, Barhholomew D, Bates G. The antimicrobial defense mechanism of the female urethra: a reassessment. J Urol. 2002;168:413–9.CrossRefPubMedGoogle Scholar
  20. 20.
    Berg RW, Milligan MC, Sarbaugh FC. Association of skin wetness and pH with diaper dermatitis. Pediatr Dermatol. 1994;11:18–20.CrossRefPubMedGoogle Scholar
  21. 21.
    Fluhr JW, Kao J, Jain M, et al. Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity. J Invest Dermatol. 2001; 117:44–51.CrossRefPubMedGoogle Scholar
  22. 22.
    Mauro TM. SC pH: measurement, origins, and functions. In: Elias PM, Feingold KR, editors. Skin barrier. New York: Taylor & Francis; 2006. p. 225.Google Scholar
  23. 23.
    Hachem JP, Crumrine D, Fluhr J, Brown BE, Feingold KR, Elias PM. pH directly regulates epidermal permeability barrier homeostasis and stratum corneum integrity/cohesion. J Invest Dermatol. 2003;121:345–53.CrossRefPubMedGoogle Scholar
  24. 24.
    Falabella AF, Falanga V. Wound Healing. In: Freinkel RK, Woodley DT, editors. The biology of the skin. New York: Parthenon Publishing; 2001. p. 281–97.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.University of Utah School of MedicineSalt Lake CityUSA

Personalised recommendations