Sulfadoxine Pyrimethamine Resistance
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This compound is used in Africa for intermittent preventive therapy in pregnant women (IPTp) and infants (IPTi). The resistance of some Plasmodium falciparum strains against a treatment with sulfadoxine pyrimethamine is due to the fact that resistant strains show a mutation in the genes Pfdhfr (P. falciparum dihydrofolate reductase) and Pfdhps (P. falciparum dihydropteroate synthase). These apparently progressing resistances endanger any mass treatment. In three foci of East Africa the populations are already fully resistant.