Encyclopedia of Parasitology

2016 Edition
| Editors: Heinz Mehlhorn


  • Heinz MehlhornEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-662-43978-4_4333

This term describes metalloenzymes which catalyze dismutation of O2- to H2O2. SODs in trypanosomatid parasites are exclusively dependent on iron for their activity, while mammals contain Cu/Zn- and Mn-dependent SODs in the mitochondrial matrix and in cytoplasm. Leishmania species have in total three functionally characterized FeSODs. Two isoforms of them have been localized in the glycosomes, which contain enzymes involved in the glycolytic pathway.

Further Readings

  1. Taylor MC, Kelly JM (2010) Iron metabolism in trypanosomatids and its crucial role in infection. Parasitology 137:899–917PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Institut für ZoomorphologieZellbiologie und Parasitologie, Heinrich-Heine-UniversitätDüsseldorfGermany