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Piperonylbutoxide (PBO), n-octyl bicycloheptene dicarboximide (MGK 264).
Synergists usually enhance the efficacy of an arthropodicidal drugwithout displaying toxic effects by themselves. In most cases synergists are thought to act by inhibiting metabolism of a given drug and in this context can be used at least, sometimes to prolong the activity of a compound in resistant parasite strains. PBO, one of the most frequently used synergists, inhibits cytochrome P-450 microsomal monooxygenases, and is used together with DEET ( Repellents) and pyrethrins ( Arthropodicidal Drugs/Pyrethroids and DDT) to control lice and biting midges on companion animals.