Encyclopedia of Parasitology

2016 Edition
| Editors: Heinz Mehlhorn

Synergists

Reference work entry
DOI: https://doi.org/10.1007/978-3-662-43978-4_3073
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Important Compound

Piperonylbutoxide (PBO), n-octyl bicycloheptene dicarboximide (MGK 264).

General Information

Synergists usually enhance the efficacy of an  arthropodicidal drugwithout displaying toxic effects by themselves. In most cases synergists are thought to act by inhibiting metabolism of a given drug and in this context can be used at least, sometimes to prolong the activity of a compound in resistant parasite strains. PBO, one of the most frequently used synergists, inhibits cytochrome P-450 microsomal monooxygenases, and is used together with DEET ( Repellents) and pyrethrins ( Arthropodicidal Drugs/Pyrethroids and DDT) to control  lice and biting  midges on companion animals.

Copyright information

© Springer-Verlag Berlin Heidelberg 2016