Encyclopedia of Parasitology

2016 Edition
| Editors: Heinz Mehlhorn

Sporozoite’s Liver Invasion

Reference work entry
DOI: https://doi.org/10.1007/978-3-662-43978-4_2967

Malarial sporozoites that enter the liver parenchyma of their hosts have to pass through a cascade of events: binding to extracellular matrix proteoglycans, passage through Kupffer cells, transmigration through several hepatocytes until the final cell is invaded. The sporozoite thus exploits the properties of the liver to evade the immune system.

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© Springer-Verlag Berlin Heidelberg 2016