Encyclopedia of Parasitology

2016 Edition
| Editors: Heinz Mehlhorn

Serology

  • Ingrid Reiter-Owona
  • Hans Martin Seitz
Reference work entry
DOI: https://doi.org/10.1007/978-3-662-43978-4_2874

Synonyms

Antibody detection; Immunodiagnosis; Serodiagnosis

General Information

Serology in general, which describes changes in the immunological potency of body fluids after infection with a specific pathogen under diagnostic aspects, has gained increasing importance over the last 20 years for microbiology. Serology of parasitic infections, in particular, gained much from the in vitro cultivation of parasites and the production of monoclonal antibodies. Both techniques together improved the knowledge of parasitologists on stage-specific antigens and antibodies and their relevance for immunodiagnosis. A variety of potential  immunoassayswere developed to measure the change in kinetics and concentration of parasite-specific antibodies. The technical developments favoured the ELISA-system, as it needs only minor quantities of reagents and it can equally be used for antigen and antibody detection. The application of highly specialized test systems showed clearly that serological values...

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Ingrid Reiter-Owona
    • 1
  • Hans Martin Seitz
    • 1
  1. 1.Institut für medizinische ParasitologieUniversität BonnBonnGermany