Encyclopedia of Parasitology

2016 Edition
| Editors: Heinz Mehlhorn

Secrotome

Reference work entry
DOI: https://doi.org/10.1007/978-3-662-43978-4_2854
This system transports parasite proteins to the  Maurer’s clefts (MC) – resembling Golgi- lamella – in Plasmodium-infected red blood cells via 2 ways:
  1. 1.

    Vesicles are secreted from the lumen of the parasitophorus vacuole, which join the MC.

     
  2. 2.

    Proteins are translocated across the vacuolar membrane into host cell cytosol and become associated with the cytoplasmic face of the MC.

     

Both processes are steered by a host-targeting signal (HT) and finally lead to transport of parasite protein into the host cell.

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© Springer-Verlag Berlin Heidelberg 2016