Congenital Hyperinsulinism

  • Augusto ZaniEmail author
  • Agostino Pierro
Reference work entry


Congenital hyperinsulinism (CHI) comprises a group of disorders characterized by excessive insulin secretion from pancreatic β-cells, resulting in severe hypoglycemia. In neonates and infants, CHI is considered the most frequent cause of persistent hypoglycemia. Prompt diagnosis and treatment are crucial as a delay may cause severe brain damage and long-term neurodevelopmental disability. Therapeutic strategies for CHI can be medical, surgical, or combined.


Congenital hyperinsulinism Transient hyperinsulinism Persistent hyperinsulinism Hypoglycemia Pancreatectomy 


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© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Division of General and Thoracic SurgeryThe Hospital for Sick ChildrenTorontoCanada
  2. 2.Department of SurgeryUniversity of TorontoTorontoCanada
  3. 3.Division of General and Thoracic Surgery, The Hospital for Sick ChildrenUniversity of TorontoTorontoCanada

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