Immunology and Immunodeficiencies in Children

  • Saima AslamEmail author
  • Fiona O’Hare
  • Hassan Eliwan
  • Eleanor J. Molloy
Reference work entry


The immune system in neonates is different to that of adults and evolves in the first few years of life to achieve adult-like responses. This chapter highlights the response of the immune system to sepsis both in pediatric and neonatal age groups and the intricate balance between pro-inflammatory and anti-inflammatory responses to limit the damage secondary to infections. Immunodeficiencies primary or acquired are described in detail including their common presentations, common pathogens involved, the cell type involved, mechanism of deficiency, treatment, and prognosis including specific considerations for these patients prior to surgery. Immunomodulation of immune system either by alteration in ligand receptor binding or intracellular signal can help to modulate the disease process and may alter the prognosis for children with sepsis in the future.


Innate immune system Neutrophils Lymphocytes Toll-like receptors Systemic inflammatory response syndrome Natural killer cell Dendritic cells Immunomodulation Primary immunodeficiencies Acquired immunodeficiencies 


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Authors and Affiliations

  • Saima Aslam
    • 1
    • 2
    Email author
  • Fiona O’Hare
    • 1
    • 2
  • Hassan Eliwan
    • 1
    • 2
  • Eleanor J. Molloy
    • 3
    • 4
    • 5
    • 6
    • 1
    • 2
  1. 1.Discipline of PaediatricsTrinity College, The University of DublinDublinIreland
  2. 2.Tallaght Hospital and Coombe Women’s and Infants University HospitalDublinIreland
  3. 3.Department of Neonatology, Paediatrics, National Maternity HospitalDublinIreland
  4. 4.UCD School of Medicine and Medical Sciences, University College DublinDublinIreland
  5. 5.Neonatology, Our Lady’s Children’s HospitalDublinIreland
  6. 6.Paediatrics, Royal College of Surgeons in IrelandDublinIreland

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