Encyclopedia of Immunotoxicology

2016 Edition
| Editors: Hans-Werner Vohr

Systemic Autoimmunity

  • K. Michael Pollard
Reference work entry
DOI: https://doi.org/10.1007/978-3-642-54596-2_1415



Immunity consists of innate and adaptive responses. Innate immune systems are found in all classes of plant and animal life. The innate immune system is made up of specialized cells (e.g., macrophages, dendritic cells, neutrophils), which recognize and respond immediately to infection and injury in a way that does not confer long-lasting or protective immunity. The innate immune system also plays an essential role in the activation of the evolutionarily younger adaptive immune response. Unlike innate immunity, adaptive immunity is slower to respond but is highly specific, producing responses that target a particular antigen. Adaptive immunity is also the mediator of immunological memory which allows a faster, more effective response to a previously encountered antigen. Although the immune system, especially the adaptive immune system, evolved mechanisms to tolerate the tissue constituents of its...

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  1. Germolec D, Kono DH, Pfau JC, Pollard KM (2012) Animal models used to examine the role of the environment in the development of autoimmune disease: findings from an NIEHS Expert Panel Workshop. J Autoimmun 39:285–293PubMedCentralPubMedGoogle Scholar
  2. Miller FW, Alfredsson L, Costenbader KH, Kamen DL, Nelson LM, Norris JM, De Roos AJ (2012a) Epidemiology of environmental exposures and human autoimmune diseases: findings from a National Institute of Environmental Health Sciences Expert Panel Workshop. J Autoimmun 39:259–271PubMedCentralPubMedGoogle Scholar
  3. Miller FW, Pollard KM, Parks CG, Germolec DR, Leung PS, Selmi C, Humble MC, Rose NR (2012b) Criteria for environmentally associated autoimmune diseases. J Autoimmun 39:253–258PubMedCentralPubMedGoogle Scholar
  4. Selmi C, Leung PS, Sherr DH, Diaz M, Nyland JF, Monestier M, Rose NR, Gershwin ME (2012) Mechanisms of environmental influence on human autoimmunity: a National Institute of Environmental Health Sciences expert panel workshop. J Autoimmun 39:272–284PubMedGoogle Scholar
  5. Zenewicz LA, Abraham C, Flavell RA, Cho JH (2010) Unraveling the genetics of autoimmunity. Cell 140:791–797PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Molecular and Experimental MedicineThe Scripps Research InstituteLa JollaUSA