Role of Biologicals in Meniscus Surgery

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Abstract

Meniscus healing in the avascular, central zone, which includes more than two-thirds of the meniscus from the central region to the periphery, is strongly impaired, mainly because of the diminished blood supply but due to intrinsic factors. Over the last 30 years, an increasing number of research studies have focused on the enhancement of meniscus healing utilizing biologicals such blood products, growth factors, and certain types of cells including progenitor cells or surgical techniques such as synovial and meniscus rasping, needling, and trephination aiming to enhance biologically healing. The results varied significantly. Furthermore, most of these studies were in vitro or animal trials. Thus far, there has been no clear evidence to support the use of any of these biologicals. However, because of the ease of its usage and its low costs, many surgeons perform meniscus needling as well as synovial and meniscus rasping.

Keywords

Vascular Endothelial Growth Factor Mesenchymal Stem Cell Anterior Cruciate Ligament Reconstruction Fibrin Glue Medial Meniscus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Section Sports Traumatology & Arthroscopy, Center for Musculoskeletal SurgeryCharité – University Medicine BerlinBerlinGermany
  2. 2.Department of Orthopaedic and TraumatologyCity Hospital BrandenburgBrandenburgGermany

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