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Human Meniscus: From Biology to Tissue Engineering Strategies

  • Hélder Pereira
  • Ibrahim Fatih Cengiz
  • Joana Silva-Correia
  • Joaquim Miguel Oliveira
  • Rui Luís Reis
  • João Espregueira-Mendes
Living reference work entry

Later version available View entry history

Abstract

Once meniscus is damaged, a cascade of events occurs leading to degenerative joint changes of the knee. The morbidity of patients can significantly increase overtime and degeneration of the cartilage can progress, resulting in arthritis. Possibilities for treatment of meniscus lesions are primordially focused in repair and replacement (e.g., acellular scaffolds and meniscus allograft transplantation). Tissue Engineering and Regenerative Medicine have been providing new options in medical practice. However, these disciplines require deep understanding of the target tissue and physiopathology of the implicated disorder. In order to overcome the current limitations, fundamental studies have been made for developing reliable strategies aiming to obtain superior tissue healing. Herein, it is presented the most relevant insights and research directions on the fundamental biology and biomechanics of meniscus. The principles of tissue engineering (triad) and the significant in vitro and in vivo reports addressing meniscus regeneration are included, once these will provide the basements for future clinical directions.

Keywords

Tissue Engineering Lateral Meniscus Medial Meniscus Meniscus Tissue Discoid Lateral Meniscus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Hélder Pereira
    • 1
    • 2
    • 3
    • 4
  • Ibrahim Fatih Cengiz
    • 1
    • 2
  • Joana Silva-Correia
    • 1
    • 2
  • Joaquim Miguel Oliveira
    • 1
    • 2
  • Rui Luís Reis
    • 1
    • 2
  • João Espregueira-Mendes
    • 1
    • 2
    • 3
    • 4
  1. 1.3B’s Research Group – Biomaterials, Biodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of MinhoTaipas, GuimarãesPortugal
  2. 2.ICVS/3B’s – PT Government Associated LaboratoryGuimarãesPortugal
  3. 3.Clínica Espregueira-Mendes F.C. Porto Stadium – FIFA Medical Centre of ExcellencePortoPortugal
  4. 4.Orthopedic DepartmentCentro Hospitalar Póvoa de VarzimVila do CondePortugal

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