Proteomics
Synonyms
Studies on proteins expressed by the genetic material of an organism
Definition
The proteome is the genome complement of proteins, and proteomics is the study of proteomes in a cell at any given time. Neuroproteomics defines the entire protein complement of the nervous system. It represents a higher complexity than the transcriptome, and it displays a higher degree of dynamics due to posttranslational modifications (PTMs). Two main approaches of this field are profiling and functional proteomics. Profiling proteomics includes the description of the whole proteome of a cell, tissue, organ, or organism and comprises organelle mapping and differential measurement of expression levels between cells or conditions. Functional proteomics aims to characterize protein activity, by determining protein interactions and the presence of PTMs.
Current Concepts and State of Knowledge
The analysis of proteomes is significantly more challenging than that of genomes. Measuring gene expression...
References
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