Encyclopedia of Ophthalmology

Living Edition
| Editors: Ursula Schmidt-Erfurth, Thomas Kohnen

Keratoglobus Basic Science

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-35951-4_542-2



Keratoglobus is a rare, degenerative bilateral corneal disease characterized by corneal thinning and hemispherical protrusion that may lead to myopia (Lange and Gareis 2007).


Keratoglobus is characterized by thinning of the cornea from limbus to limbus (Wallang and Das 2013). Scleral thinning and minimal corneal scarring may also be involved. The cornea tends to be of normal or increased diameter with these physical changes (Karabatsas and Cook 1996). The eye will have normal to low intraocular pressure with a normal disk. Corneal edema is a rare complication of keratoglobus that increases the risk of rupture.


The cause of keratoglobus is unclear, and the pattern of corneal thinning tends to be unpredictable (Krachmer et al. 1984). Patients may report vision deterioration that affects their daily functioning. Keratoglobus does not cause blindness though.

Clinical Relevance

Keratoglobus is much more rare than...


Contact Lens Corneal Edema Corneal Dystrophy Corneal Disease Vernal Keratoconjunctivitis 
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Authors and Affiliations

  1. 1.University of Louisville OphthalmologyLouisvilleUSA