Encyclopedia of Biophysics

Living Edition
| Editors: Gordon Roberts, Anthony Watts, European Biophysical Societies

Membrane Transport Proteins: The Nucleobase-Cation-Symport-1 Family

  • Georgia F. Papadaki
  • Pikyee Ma
  • Irshad Ahmad
  • Antonio N. Calabrese
  • Stephen A. Baldwin
  • Peter J. F. Henderson
  • George Diallinas
Living reference work entry

Latest version View entry history

DOI: https://doi.org/10.1007/978-3-642-35943-9_684-3

Synonyms

Introduction

The NCS1 family, designated A.2.39 (Saier et al. 2006, 2009), consists of over 2000 currently sequenced proteins derived from Gram-negative and Gram-positive bacteria, archaea, yeast, fungi, and some plants (Pantazopoulou and Diallinas 2007; Ren et al. 2007; Ren and Paulsen 2007, 2010). Proteins of the NCS1 family are 419–635 aminoacyl residues long and possess 12 transmembrane α-helices (TMHs). Eukaryotic members of the family are also characterized by extended cytoplasmic N- and C-terminal regions, which include cis-acting elements critical for their subcellular membrane sorting and endocytic turnover (Lauwers et al. 2010; Keener and Babst 2013;...

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Copyright information

© European Biophysical Societies' Association (EBSA) 2018

Authors and Affiliations

  • Georgia F. Papadaki
    • 1
  • Pikyee Ma
    • 2
  • Irshad Ahmad
    • 2
  • Antonio N. Calabrese
    • 3
  • Stephen A. Baldwin
    • 2
  • Peter J. F. Henderson
    • 2
  • George Diallinas
    • 1
  1. 1.Department of BiologyNational and Kapodistrian University of AthensPanepistimioupolisGreece
  2. 2.Astbury Centre for Structural Molecular Biology and School of BioMedical SciencesUniversity of LeedsLeedsUK
  3. 3.Astbury Centre for Structural Molecular Biology and School of Molecular and Cellular BiologyUniversity of LeedsLeedsUK

Section editors and affiliations

  • Peter J. F. Henderson
    • 1
  1. 1.Astbury Centre for Structural Molecular Biology, Institute of Membrane and Systems BiologyUniversity of LeedsLeedsUK