Encyclopedia of Biophysics

Living Edition
| Editors: Gordon Roberts, Anthony Watts, European Biophysical Societies

Electron Transfer in Catalases and Catalase-Peroxidases

  • Anabella IvancichEmail author
  • Peter C. Loewen
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-35943-9_51-1


Catalases (EC are enzymes that catalyze the disproportionation of hydrogen peroxide into water and molecular oxygen by means of a heme iron or a dimanganese active site. They are crucial metalloproteins regulating the cellular concentration of hydrogen peroxide, which has a concentration-dependent dual role in cell signaling and oxidative stress.

Catalase-peroxidases, also named KatGs from the encoding katG gene, are heme-containing oxidoreductases capable of both the disproportionation of hydrogen peroxide and the oxidation of substrates via high-valent heme intermediates. KatGs also generate superoxide via an oxidase reaction and activate the antitubercular prodrug isoniazid (INH) through its conversion to isonicotinyl-NAD.

Basic Characteristics

Catalases are protective enzymes that efficiently decompose H 2O 2 into H 2O and O 2. They fall in three distinct phylogenetic groups: heme monofunctional catalases, heme catalase-peroxidases, and manganese catalases. The...
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Copyright information

© European Biophysical Societies' Association (EBSA) 2018

Authors and Affiliations

  1. 1.Laboratoire de Bioénergétique et Ingénierie des Protéines (UMR 7281)Aix-Marseille University, Centre National de la Recherche Scientifique (CNRS)MarseilleFrance
  2. 2.Department of MicrobiologyUniversity of ManitobaWinnipegCanada