Protein Secondary Structure Prediction in 2018
Protein secondary structure prediction aims at the prediction of secondary structure on the residue level from sequence information alone. Predicted are commonly alpha-helices and beta-strands, i.e., the most prevalent regular secondary structure segments. On the opposite side of regular secondary structure are irregular or disordered regions often referred to as loops, random coils, or disorder.
Fifteen years ago, science leaped when putting up the almost entire blueprint for human life. Now that the parts are known, can this blueprint be used as a manual to understand how the machine works? “Like with every proper manual, usually we do not find the information we need and in the rare cases that we do, we do not understand the answer” jokes Anna Tramontano (La Sapienza, Rome, 1957–2017). Every year since, new surprising findings...
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