Mechanosensitivity of Ion Channels
Mechanosensitive ion channels are molecular transducers of physical forces. They respond to mechanical stresses including shear, compressive, and tensile forces. These forces are either transmitted to the channel via the surrounding lipid bilayer or via molecular tethers. Mechanosensitive ion channels are essential components of numerous mechanosensory systems including hearing, touch, and blood pressure control. Multidisciplinary studies on mechanosensitive ion channel proteins have contributed considerably to understanding of their structure, function, and mechanisms of mechanosensory transduction.
- Bavi N, Cortes DM, Cox CD, Rohde PR, Liu W, Deitmer JW, Bavi O, Strop P, Hill AP, Rees D, Corry B, Perozo E, Martinac B (2016) The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels. Nat Commun 7:11984CrossRefPubMedPubMedCentralGoogle Scholar
- Martinac B, Cox CD (2017) Mechanosensory transduction: focus on ion channels. In: Comprehensive biophysics. Elsevier, New YorkGoogle Scholar
- Mchaourab HS, Perozo E (2002) Determination of protein folds and conformational dynamics using spin-labeling EPR spectroscopy. In: Berliner LJ, Eaton GR, Eaton SS (eds) Distance measurements in biological systems by EPR. Springer US, BostonGoogle Scholar
- Neu CP, Genin GM (2014) Handbook of imaging in biological mechanics. CRC Press Boca Raton, FloridaGoogle Scholar
- Nomura T, Cranfield CG, Deplazes E, Owen DM, Macmillan A, Battle AR, Constantine M, Sokabe M, Martinac B (2012) Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS. Proc Natl Acad Sci U S A 109:8770–8775CrossRefPubMedPubMedCentralGoogle Scholar
- Petrov E, Menon G, Rohde PR, Battle AR, Martinac B, Solioz M (2018) Xenon-inhibition of the MscL mechano-sensitive channel and the CopB copper ATPase under different conditions suggests direct effects on these proteins. PLoS ONE 13(6): e0198110Google Scholar