HADDOCK (High Ambiguity Driven biomolecular DOCKing) is an information-driven flexible docking approach for the modeling of biomolecular complexes (Dominguez et al. 2003). Docking is defined as the modeling of the structure of a complex based on the known three-dimensional structures of its constituents. HADDOCK distinguishes itself from other docking methods by incorporating a wide variety of experimental and/or bioinformatics data to drive the modeling (Melquiond and Bonvin 2010; Rodrigues and Bonvin 2014). This allows concentrating the search to relevant portions of the interaction space using a more sophisticated treatment of conformational flexibility.
- Melquiond ASJ, Bonvin AMJJ (2010) Data-driven docking: using external information to spark the biomolecular rendez-vous. In: Zacharrias M (ed) Protein-protein complexes: analysis, modeling and drug design. Imperial College Press, London, pp 183–209Google Scholar