Living reference work entry
Functional amyloid is a fibrillar protein assembly with the same structural, morphological, and dye-binding properties that characterize disease-causing or disease-associated amyloid fibrils but whose production or application is beneficial to the organism and not associated with protein misfolding or pathology (Pham et al. 2014). Proteins that form functional amyloid contain amyloidogenic motifs that provide self-assembly capability and the biologically active form of the protein is retained or generated in the fibrillar form (Fig. 1). The amyloid, multimeric version of the protein has properties beyond that of the monomeric component protein. In functional amyloid structures, the self-assembly properties of amyloid fibrils, and the stability and resistance to proteolysis of the amyloid structure, are applied for a wide range of biological functions including production of protective coatings, development of mechanical strength, control of cytotoxic intermediates,...
- Loquet A, Saupe SJ (2017) Diversity of amyloid motifs in NLR signaling in Fungi. Biomol Ther 7. https://doi.org/10.3390/biom7020038
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