Encyclopedia of Biophysics

Living Edition
| Editors: Gordon Roberts, Anthony Watts, European Biophysical Societies

Entropy-Enthalpy Compensation

  • Athel Cornish-Bowden
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-35943-9_10072-1

Synonyms

Introduction

Enthalpy–entropy compensation is the concept that differences in the standard enthalpy of reaction ΔH0 for different reactions may be compensated for by differences in the standard entropy of reaction ΔS0, and that such compensation is so common as to be almost universal. The concept applies equally to kinetic data, variations in the enthalpy of activation ΔH being compensated for by variations in the entropy of activation ΔS. Thermodynamic data are usually obtained from van ’t Hoff plots and activation data from Arrhenius plots. Calorimetric measurements in principle allow enthalpies and entropies to be measured independently and are less susceptible to some of the difficulties discussed here.

Enthalpy–entropy compensation derives ultimately from an observation almost a century ago of a straight-line relation between the logarithm of the frequency factor and...

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Copyright information

© European Biophysical Societies’ Association (EBSA) 2018

Authors and Affiliations

  1. 1.Aix Marseille University, CNRS, BIP, IMMMarseilleFrance

Section editors and affiliations

  • Alan Cooper
    • 1
  1. 1.School of Chemistry, University of GlasgowGlasgowUK