Quantitative and Theoretical Microbial Population Biology

Abstract

Microbes are extraordinarily diverse, not only in terms of their genetics and metabolism, but even in the fundamental evolutionary processes that give rise to their diversity. Because the biological species concept, largely developed for vertebrate animals, does not apply to bacteria and archaea, it has been challenging to conceptualize what a microbial population should be. However, recent evidence suggests that akin to populations of animals and plants, genotypic clusters can be recognized among co-existing microbes. These represent tractable units to address fundamental ecological and evolutionary questions with first results suggesting cohesive ecological properties in spite of high genetic diversity within clusters. Progress in genomic sequencing and computational tools are leading toward an integrated understanding of how mutation, recombination and gene transfer combine with selection to create microbial diversity, and how populations adapt to novel environmental challenges.

Keywords

Internal Transcribe Spacer Homologous Recombination Acid Mine Drainage Geographic Isolation Approximate Bayesian Computation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

We thank Nick Croucher for valuable discussions and suggestions. Funding was provided by the National Science Foundation, the National Institutes of Health and the Gordon and Betty Moore Foundation.

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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Parsons Laboratory, Department of Civil and Environmental EngineeringMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.Department of EpidemiologyHarvard School of Public HealthBostonUSA

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