Oxidative Stress and Abdominal Aortic Aneurysms
- 211 Downloads
The role of inflammation in the pathogenesis of abdominal aortic aneurysm (AAA) is well established. Reactive oxygen species (ROS) as products of localized inflammation process can cause a gradual degradation of the extracellular matrix through an upregulation of matrix metalloproteinases and apoptosis of smooth muscle cells (SMC) of the vascular wall, which is associated with localized structural deterioration and progressive aortic dilatation.
Oxidative stress not only has a key role in pathogenesis of AAA but also during AAA repair. It is likely to result as a response to an ischemia/reperfusion injury (IRI) to the lower limbs and gastrointestinal tract. Modulation of ROS production or activity and restriction of the oxidative stress degree may suppress AAA formation and improve AAA repair results.
KeywordsAbdominal aortic aneurysm Oxidative stress ROS
- Alsac JM, Journe C, Louedec L, Dai J, Julia P, Fabiani JN, Michel JB (2011) Downregulation of remodelling enzymatic activity induced by an angiotensin-converting enzyme inhibitor (perindopril) reduces the degeneration of experimental abdominal aortic aneurysms in a rat model. Eur J Vasc Endovasc Surg 41(4):474–480PubMedCrossRefGoogle Scholar
- Chello M, Mastroroberto P, Romano R, Castaldo P, Bevacqua E, Marchese AR (1996) Protection by coenzyme Q10 of tissue reperfusion injury during abdominal aortic cross-clamping. J Cardiovasc Surg (Torino) 37(3):229–35Google Scholar
- Ejiri J, Inoue N, Tsukube T, Munezane T, Hino Y, Kobayashi S, Hirata K, Kawashima S, Imajoh-Ohmi S, Hayashi Y, Yokozaki H, Okita Y, Yokoyama M (2003) Oxidative stress in the pathogenesis of thoracic aortic aneurysm. Protective role of statin and angiotensin II type 1 receptor blocker. Cardiovasc Res 59:988–996PubMedCrossRefGoogle Scholar
- Gavrila D, Li W-G, Daugherty A, Cassis LA, Miller FJ Jr, Oberley LW, Dellsperger KC, Weintraub NL (2005) Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused, apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 25:1671–1677PubMedCentralPubMedCrossRefGoogle Scholar
- Inoue N, Muramatsu M, Jin D, Takai S, Hayashi T, Katayama H, Kitaura Y, Tamai H, Miyazaki M (2009a) Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient mice. J Atheroscler Thromb 16(3):164–171PubMedCrossRefGoogle Scholar
- Morita T, Imai T, Yamaguchi T, Sugiyama T, Katayama S, Yoshino G (2003) Induction of heme oxygenase-1 in monocytes suppresses angiotensin II-elicited chemotactic activity through inhibition of CCR2: role of bilirubin and carbon monoxide generated by the enzyme. Antioxid Redox Signal 5:439–447PubMedCrossRefGoogle Scholar
- Papalambros E, Sigala F, Georgopoulos S, Paraskevas KI, Andreadou I, Menenakos X, Sigalas P, Papalambros AL, Vourliotakis G, Giannopoulos A, Bakoyiannis C, Bastounis E (2007) Malondialdehyde as an indicator of oxidative stress during abdominal aortic aneurysm repair. Angiology 58(4):477–482PubMedCrossRefGoogle Scholar
- Pyo R, Lee JK, Shipley JM, Curci JA, Mao D, Ziporin SJ, Ennis TL, Shapiro SD, Senior RM, Thompson RW (2000) Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest 105:1641–1649PubMedCentralPubMedCrossRefGoogle Scholar
- Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, Galis ZS (1996) Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest 98:2572–2579PubMedCentralPubMedCrossRefGoogle Scholar
- Zhao L, Moos MP, Grabner R, Pedrono F, Fan J, Kaiser B, John N, Schmidt S, Spanbroek R, Lotzer K, Huang L, Cui J, Rader DJ, Evans JF, Habenicht AJ, Funk CD (2004) The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat Med 10:966–973PubMedCrossRefGoogle Scholar