Oxidative Stress and Abdominal Aortic Aneurysms
The role of inflammation in the pathogenesis of abdominal aortic aneurysm (AAA) is well established. Reactive oxygen species (ROS) as products of localized inflammation process can cause a gradual degradation of the extracellular matrix through an upregulation of matrix metalloproteinases and apoptosis of smooth muscle cells (SMC) of the vascular wall, which is associated with localized structural deterioration and progressive aortic dilatation.
Oxidative stress not only has a key role in pathogenesis of AAA but also during AAA repair. It is likely to result as a response to an ischemia/reperfusion injury (IRI) to the lower limbs and gastrointestinal tract. Modulation of ROS production or activity and restriction of the oxidative stress degree may suppress AAA formation and improve AAA repair results.
KeywordsAbdominal aortic aneurysm Oxidative stress ROS
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