Oxidative Stress in Surgery

Reference work entry


Reactive oxygen species (ROS) play both physiological and pathophysiological roles in the body. In clinical practice, oxidative stress and its counterpart, antioxidant capacity, can be measured and can guide remedial therapy. Oxidative stress can make a negative impact in all forms of major surgery including cardiac surgery, general surgery, trauma surgery, orthopedic surgery, and plastic surgery. Many and various therapies aimed at reducing oxidative stress in surgery have been tried with variable results. We conclude that in surgical patients, the assessment of oxidative stress, improving understanding of its role, both positive and negative, and devising appropriate therapies are of great clinical importance and represent fruitful fields for further research.


Antioxidant capacity Free radicals Oxidative stress Reactive oxygen species Surgery 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Cardiac Surgical Research Unit, Department of Cardiothoracic SurgeryAlfred HospitalMelbourneAustralia
  2. 2.Department of SurgeryMonash UniversityMelbourneAustralia
  3. 3.Centre for Human PsychopharmacologySwinburne University of TechnologyMelbourneAustralia
  4. 4.Oxidative Stress Laboratory, Diabetic Complications DivisionBaker IDI Heart and Diabetes InstituteMelbourneAustralia

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