Encyclopedia of Pain

2013 Edition
| Editors: Gerald F. Gebhart, Robert F. Schmidt

Viral Neuropathies

Reference work entry
DOI: https://doi.org/10.1007/978-3-642-28753-4_4777

Synonyms

Definition

Neuropathies that are associated with viral infection.

Introduction

Virus-induced neuropathy is an important cause of painful peripheral neuropathies. Pain is often the most prominent symptom after a virus causes destruction to a nerve. The mechanisms by which viruses can induce pain include direct infection of neurons or nerve fibers; they may also cause indirect nerve destruction by activating an immune-mediated inflammatory response. In this chapter, we will focus on a few important viruses that may cause painful peripheral neuropathies.

Characteristics

Human Immunodeficiency Virus (HIV)

Epidemiology

Distal sensory polyneuropathy (DSP) is a common neurologic complication and major cause of morbidity in HIV-infected patients (Gonzalez-Duarte et al. 2008). The estimated incidence of DSP is 30 %, with a prevalence ranging from 25 % to 53 % (Morgello et al. 2004). Risk factors that are associated with a higher...

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References

  1. Ammendola, A., Sampaolo, S., Ambrosone, L., et al. (2005). Peripheral neuropathy in hepatitis related mixed cryoglobulinemia: Electrophysiologic follow up study. Muscle & Nerve, 31, 382–385.Google Scholar
  2. Cornblath, D. R., & McArthur, J. C. (1988). Predominantly sensory neuropathy in patients with AIDS and AIDS-related complex. Neurology, 38, 794–796.PubMedGoogle Scholar
  3. Dworkin, R. H., & Portenoy, R. K. (1996). Pain and its persistence in herpes zoster. Pain, 67(2–3), 241–251.PubMedGoogle Scholar
  4. Gonzalez-Duarte, A., Robinson-Papp, J., & Simpson, D. M. (2008). Diagnosis and management of HIV-associated neuropathy. Neurologic Clinics, 26(3), 821–832.PubMedGoogle Scholar
  5. Gorwon, K. C., Herrmann, D. N., et al. (2007). Non-length dependent small fiber neuropathy/ganglionopathy. Journal of Neurology, Neurosurgery, and Psychiatry, 79, 163–169.Google Scholar
  6. Hahn, K., Arendt, G., Braun, J. S., et al. (2004). A placebo-controlled trial of gabapentin for painful HIV-associated sensory neuropathie. Journal of Neurology, 251, 1260–1266.PubMedGoogle Scholar
  7. Holland, N., Stocks, A., Hauer, P., et al. (1997). Intraepidermal nerve fiber density in patients with painful sensory neuropathy. Neurology, 48, 708–711.PubMedGoogle Scholar
  8. Iannuzzella, F., Vaglio, A., & Garini, G. (2010). Management of hepatitis C virus-related mixed cryoglobulinemia. American Journal of Medicine, 123(5), 400–408.PubMedGoogle Scholar
  9. Kost, R. G., & Straus, S. E. (1997). Postherpetic neuralgia. Predicting and preventing risk. Archives of Internal Medicine, 157(11), 1166–1167.PubMedGoogle Scholar
  10. Kotani, N., Kushikata, T., Hashimoto, H., Kimura, F., Muraoka, M., Yodono, M., et al. (2000). Intrathecal methylprednisolone for intractable postherpetic neuralgia. The New England Journal of Medicine, 343, 1514–1519.PubMedGoogle Scholar
  11. Luciano, C. A., Pardo, C. A., & McArthur, J. C. (2003). Recent developments in the HIV neuropathies. Current Opinion in Neurology, 16, 403–409.PubMedGoogle Scholar
  12. McArthur, J. C., Yiannoutsos, C., Simpson, D. M., & ACTG Clinical Trials Group Team 291. (2000). A phase II trial of recombinant human nerve growth factor for sensory neuropathy associated with HIV infection. Neurology, 54, 1080–1088.PubMedGoogle Scholar
  13. Morgello, S., Estanislao, L., Simpson, D., et al. (2004). HIV-associated distal sensory polyneuropathy in the era of highly active antiretroviral therapy: the Manhattan HIV brain bank. Archives of Neurology, 61, 546–551.PubMedGoogle Scholar
  14. Nemni, R., Sanvito, L., et al. (2003). Peripheral neuropathy in hepatitis C virus infection with and without cryoglobulinemia. Journal of Neurology, Neurosurgery, and Psychiatry, 74, 1267–1271.PubMedGoogle Scholar
  15. Simpson, D. M., Kitch, D., Evans, S. R., et al. (2006). HIV neuropathy natural history cohort study: Assessment measures and risk factors. Neurology, 66, 1679–1687.PubMedGoogle Scholar
  16. Simpson, D. M., Brown, S., Tobias, J., et al. (2008). Controlled trial of high-concentration capsaicin patch for treatment of HIV neuropathy. Neurology, 70(24), 2305–2313.PubMedGoogle Scholar
  17. Simpson, D. M., Schifitto, G., Clifford, D. B., et al. (2010). Pregabalin for painful HIV neuropathy: A randomized, double-blind, placebo-controlled trial. Neurology, 74(5), 413–420.PubMedGoogle Scholar
  18. Verma, Ashok. (2001). Epidemiology and clinical features of HIV-1 associated neuropathies. Journal of the Peripheral Nervous System, 6, 8–13.PubMedGoogle Scholar
  19. Wulff, E. A., Wang, A. K., & Simpson, D. M. (2000). HIV associated peripheral neuropathy. Drugs, 59(6), 1251–1260.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.NeurologyMount Sinai School of MedicineNew YorkUSA
  2. 2.Clinical Neurophysiology LaboratoriesMount Sinai Medical CenterNew YorkUSA