Definition
Aseptic inflammatory monoarthritis induced by injections of kaolin and carrageenan into the synovial cavity of one knee joint results in damage to the cartilage, inflammation of the synovia and synovial fluid exudates, as well as pain behavior and neuroplastic changes in the peripheral and central nervous system.
Characteristics
The K/C arthritis is a well-established model of an acute onset monoarthritis resembling osteoarthritis, which is characterized by degeneration of hyaline articular cartilage and subsequent inflammation and pain. The K/C arthritis model has been used in cats (Coggeshall et al. 1983; Schaible and Grubb 1993), monkeys (Dougherty et al. 1992), rats (Neugebauer et al. 1993; Sluka and Westlund 1993), mice (Zhang et al. 2001; Gatta et al. 2012), and guinea pigs (Gomis et al. 2007) to study pain...
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References
Coggeshall, R. E., Hong, K. A., Langford, L. A., et al. (1983). Discharge characteristics of fine medial articular afferents at rest and during passive movements of inflamed knee joints. Brain Research, 272, 185–188.
Dougherty, P. M., Sluka, K. A., Sorkin, L. S., et al. (1992). Neural changes in acute arthritis in monkeys. I. Parallel enhancement of responses of spinothalamic tract neurons to mechanical stimulation and excitatory amino acids. Brain Research Reviews, 55, 1–13.
Gatta, L., Piscitelli, F., Giordano, C., Boccella, S., Lichtman, A., Maione, S., & Di Marzo, V. (2012). Discovery of prostamide F2alpha and its role in inflammatory pain and dorsal horn nociceptive neuron hyperexcitability. PLoS One, 7, e31111.
Gomis, A., Miralles, A., Schmidt, R. F., & Belmonte, C. (2007). Nociceptive nerve activity in an experimental model of knee joint osteoarthritis of the guinea pig: Effect of intra-articular hyaluronan application. Pain, 130, 126–136.
Ji, G., Sun, H., Fu, Y., Li, Z., Pais-Vieira, M., Galhardo, V., & Neugebauer, V. (2010). Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation. The Journal of Neuroscience, 30, 5451–5464.
Lawand, N. B., McNearney, T., & Westlund, K. N. (2000). Amino acid release into the knee joint: Key role in nociception and inflammation. Pain, 86, 69–74.
Neugebauer, V., & Li, W. (2003). Differential sensitization of amygdala neurons to afferent inputs in a model of arthritic pain. Journal of Neurophysiology, 89, 716–727.
Neugebauer, V., Lucke, T., & Schaible, H.-G. (1993). N-methyl-D-aspartate (NMDA) and Non-NMDA receptor antagonists block the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat’s knee joint. Journal of Neurophysiology, 70, 1365–1377.
Neugebauer, V., Li, W., Bird, G. C., et al. (2003). Synaptic plasticity in the amygdala in a model of arthritic pain: Differential roles of metabotropic glutamate receptors 1 and 5. The Journal of Neuroscience, 23, 52–63.
Neugebauer, V., Han, J. S., Adwanikar, H., Fu, Y., & Ji, G. (2007). Techniques for assessing knee joint pain in arthritis. Molecular Pain, 3, 8–20.
Schaible, H.-G., & Grubb, B. (1993). Afferent and spinal mechanisms of joint pain. Pain, 55, 5–54.
Schaible, H.-G., Ebersberger, A., & von Banchet, G. S. (2002). Mechanisms of pain in arthritis. Annals of the New York Academy of Sciences, 966, 343–354.
Sluka, K. A. (1996). Pain mechanisms involved in musculoskeletal disorders. J Orthop Sports Phys Ther 24: 240–254.
Sluka, K. A., & Westlund, K. N. (1993). Behavioral and immunohistochemical changes in an experimental arthritis model in rats. Pain, 55, 367–377.
Sluka, K. A., Rees, H., Westlund, K. N., et al. (1995). Fiber types contributing to dorsal root reflexes induced by joint inflammation in cats and monkeys. Journal of Neurophysiology, 74, 981–989.
Urban, M. O., Zahn, P. K., & Gebhart, G. F. (1999). Descending facilitatory influences from the rostral medial medulla mediate secondary, but not primary hyperalgesia in the rat. The Journal of Neuroscience, 90, 349–352.
Yang, L. C., Marsala, M., & Yaksh, T. L. (1996). Characterization of time course of spinal amino acids, citrulline and PGE2 release after carrageenan/kaolin-induced knee joint inflammation: A chronic microdialysis study. Pain, 67, 345–354.
Yu, Y. C., Koo, S. T., Kim, C. H., et al. (2002). Two variables that can be used as pain indices in experimental animal models of arthritis. Journal of Neuroscience Methods, 115, 107–113.
Zhang, L., Hoff, A. O., Wimalawansa, S. J., et al. (2001). Arthritic calcitonin/[alpha] calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity. Pain, 89, 265–273.
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Neugebauer, V. (2013). Arthritis Model, Kaolin-Carrageenan-Induced Arthritis (Knee). In: Gebhart, G.F., Schmidt, R.F. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28753-4_283
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DOI: https://doi.org/10.1007/978-3-642-28753-4_283
Publisher Name: Springer, Berlin, Heidelberg
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