Migraine is one of the most common neurological disorders and is observed in about 11 % of the world population . Migraine attacks are characterized by unilateral, throbbing and moderate-to-severe headache lasting 4–72 h, typically accompanied by nausea and photo- and phonophobia . In approximately 20 % of patients, the migraine can also be preceded by transient neurological symptoms (aura) that usually develop gradually over >5 min and last for <60 min. Auras are most frequently visual (>90 %), but may also involve other sensory symptoms (pins and needles, numbness), hemiparesis or speech deficits. Visual symptom (aura) often has a bimodal progression with positive symptom (scintillating) followed by negative symptom (scotoma). To date, the trigger mechanisms of migraine with aura are cortical spreading depression (CSD). Migraine with aura (MWA) is diagnosed according to the operational diagnostic criteria of The International Classification of Headache...
KeywordsVisual Cortex Negative Symptom Occipital Lobe Migraine With Aura Cortical Spreading Depression
- 2.Society, H.C.C.o.t.I.H.: The international classification of headache disorders, 3rd edition (beta version). Cephalalgia 33, 629–808 (2013)Google Scholar
- 3.Aiba, S., Tatsumoto, M., Saisu, A., Iwanami, H., Chiba, K., Senoo, T., Hirata, K.: Prevalence of typical migraine aura without headache in Japanese ophthalmology Clinics. Cephalalgia 30, 962–967 (2010)Google Scholar
- 5.Leão, A.A.P.: Spreading depression of activity in the cerebral cortex. J. Neurophysiol. 7, 359–390 (1944)Google Scholar
- 6.Somjen, G.G.: Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiol. Rev. 81, 1065–1096 (2001)Google Scholar