Pediatric Nephrology pp 1-25 | Cite as
Hemodialysis in Children
Abstract
Chronic dialysis, including both hemodialysis and peritoneal dialysis, is technically feasible in children of all ages, including neonates [1]. In countries with active pediatric transplant programs, however, dialysis would not be the first choice of renal replacement therapy, as most pediatric nephrologists would aim for preemptive transplants in their patients. Despite that aim, across Europe half of patients start renal replacement therapy on peritoneal dialysis and one third on hemodialysis, and only the remainder are transplanted preemptively [2]. Some children will inevitably require a period on dialysis, such as the infant in whom dialysis may be necessary until adequate size for transplant is reached, the child needing urgent treatment because of presentation in end-stage kidney disease, and children needing native nephrectomies pre-transplant. Furthermore, only a minority of children are able to escape a period of dialysis either while waiting for their first transplant or because of subsequent graft failure. This means that overall, at any time, around 20 % of the pediatric end-stage kidney disease population is dialyzed [3, 4].
Keywords
Peritoneal Dialysis Renal Replacement Therapy Blood Flow Rate Dialysis Session Blood PumpReferences
- 1.Rees L. Paediatrics: infant dialysis-what makes it special? Nat Rev Nephrol. 2013;9(1):15–7.CrossRefPubMedGoogle Scholar
- 2.Watson AR, Hayes WN, Vondrak K, Ariceta G, Schmitt CP, Ekim M, Fischbach M, Edefonti A, Shroff R, Holta T, Zurowska A, Klaus G, Bakkaloglu S, Stefanidis CJ, Van de Walle J, European Paediatric Dialysis Working Group. Factors influencing choice of renal replacement therapy in European paediatric nephrology units. Pediatr Nephrol. 2013;28(12):2361–8.CrossRefPubMedGoogle Scholar
- 3.
- 4.
- 5.Fadrowski JJ, Frankenfield D, Amaral S, Brady T, Gorman GH, Warady B, Furth SL, Fivush B, Neu AM. Children on long-term dialysis in the United States: findings from the 2005 ESRD clinical performance measures project. Am J Kidney Dis. 2007;50:958–66.CrossRefPubMedGoogle Scholar
- 6.Fontana I, Santori G, Ginevri F, Beatini M, Bertocchi M, Bonifazio L, Saltalamacchia L, Ghinolfi D, Perfumo F, Valente U. Impact of pretransplant dialysis on early graft function in pediatric kidney recipients. Transpl Int. 2005;18:785–93.CrossRefPubMedGoogle Scholar
- 7.Groothoff JW. Long-term outcomes of children with end-stage renal disease. Pediatr Nephrol. 2005;20:849–53.CrossRefPubMedGoogle Scholar
- 8.Seikaly MG, Salhab N, Browne R. Patterns and time of initiation of dialysis in US children. Pediatr Nephrol. 2005;20:982–8.CrossRefPubMedGoogle Scholar
- 9.van Stralen KJ, Tizard EJ, Jager KJ, et al. Determinants of eGFR at start of renal replacement therapy in paediatric patients. Nephrol Dial Transplant. 2010;25(10):3325–32.CrossRefPubMedGoogle Scholar
- 10.Vanholder R, Van Laecke S, Glorieux G. What is new in uremic toxicity? Pediatr Nephrol. 2008;23(8):1211–21.PubMedCentralCrossRefPubMedGoogle Scholar
- 11.Hothi D. Designing technology to meet the therapeutic demands of acute renal injury in neonates and small infants. Pediatr Nephrol. 2014;29:1869.CrossRefPubMedGoogle Scholar
- 12.Hothi DK, Stronach L, Harvey E. Home haemodialysis. Pediatr Nephrol. 2013;28:721–30.CrossRefPubMedGoogle Scholar
- 13.
- 14.Goldstein SL, Leung JC, Silverstein DM. Pro- and anti-inflammatory cytokines in chronic pediatric dialysis patients: effect of aspirin. Clin J Am Soc Nephrol. 2006;1:979–86.CrossRefPubMedGoogle Scholar
- 15.Saran R, Bragg-Gresham JL, Levin NW, Twardowski ZJ, Wizemann V, Saito A, Kimata N, Gillespie BW, Combe C, Bommer J, Akiba T, Mapes DL, Young EW, Port FK. Longer treatment time and slower ultrafiltration in hemodialysis: associations with reduced mortality in the DOPPS. Kidney Int. 2006;69:1222–8.CrossRefPubMedGoogle Scholar
- 16.Springel T, Laskin B, Shults J, Keren R, Furth S. Longer interdialytic interval and cause-specific hospitalization in children receiving chronic dialysis. Nephrol Dial Transplant. 2013;28(10):2628–36.PubMedCentralCrossRefPubMedGoogle Scholar
- 17.Müller D, Zimmering M, Chan CT, McFarlane PA, Pierratos A, Querfeld U. Intensified hemodialysis regimens: neglected treatment options for children and adolescents. Pediatr Nephrol. 2008;23:1729–36.CrossRefPubMedGoogle Scholar
- 18.Goldstein SL, Silverstein DM, Leung JC, Feig DI, Soletsky B, Knight C, Warady BA. Frequent hemodialysis with NxStagetrade mark system in pediatric patients receiving maintenance hemodialysis. Pediatr Nephrol. 2008;23:129–35.CrossRefPubMedGoogle Scholar
- 19.Geary DF, Piva E, Tyrrell J, Gajaria MJ, Picone G, Keating LE, Harvey EA. Home nocturnal hemodialysis in children. J Pediatr. 2005;147:383–7.CrossRefPubMedGoogle Scholar
- 20.Fischbach M, Terzic J, Menouer S, Dheu C, Soskin S, Helmstetter A, Burger MC. Intensified and daily hemodialysis in children might improve statural growth. Pediatr Nephrol. 2006;21:1746–52.CrossRefPubMedGoogle Scholar
- 21.Hothi DK, Harvey E, Piva E, Keating L, Secker D, Geary DF. Calcium and phosphate balance in adolescents on home nocturnal haemodialysis. Pediatr Nephrol. 2006;21:835–41.CrossRefPubMedGoogle Scholar
- 22.de Camargo MF, Henriques CL, Vieira S, Komi S, Leão ER, Nogueira PC. Growth of children with end-stage renal disease undergoing daily hemodialysis. Pediatr Nephrol. 2014;29(3):439–44.CrossRefPubMedGoogle Scholar
- 23.Thumfart J, Puttkamer CV, Wagner S, Querfeld U, Müller D. Hemodiafiltration in a pediatric nocturnal dialysis program. Pediatr Nephrol. 2014;29(8):1411–6.CrossRefPubMedGoogle Scholar
- 24.Jain SR, Smith L, Brewer ED, Goldstein SL. Non-invasive intravascular monitoring in the pediatric haemodialysis population. Pediatr Nephrol. 2001;16:15–8.CrossRefPubMedGoogle Scholar
- 25.Davenport A. Alternatives to standard unfractionated heparin for pediatric hemodialysis treatments. Pediatr Nephrol. 2012;27(10):1869–79.PubMedCentralCrossRefPubMedGoogle Scholar
- 26.Hothi DK, Rees L, McIntyre CW, Marek J. Hemodialysis-induced acute myocardial dyssynchronous impairment in children. Nephron Clin Pract. 2013;123(1–2):83–92.CrossRefPubMedGoogle Scholar
- 27.Penne EL, van der Weerd NC, Blankestijn PJ, van den Dorpel MA, Grooteman MP, Nube MJ, Ter Wee PM, Levesque R, Bots ML. Role of residual kidney function and convective volume on change in beta2-microglobulin levels in hemodiafiltration patients. Clin J Am Soc Nephrol. 2010;5:80–6.PubMedCentralCrossRefPubMedGoogle Scholar
- 28.Chand DH, Brier M, Strife CF. Comparison of vascular access type in pediatric hemodialysis patients with respect to urea clearance, anemia management, and serum albumin concentration. Am J Kidney Dis. 2005;45:303–8.CrossRefPubMedGoogle Scholar
- 29.Fischbach M, Edefonti A, Schröder C, Watson A, The European Pediatric Dialysis Working Group. Hemodialysis in children: general practical guidelines. Pediatr Nephrol. 2005;20:1054–66.PubMedCentralCrossRefPubMedGoogle Scholar
- 30.Ma A, Shroff R, Hothi D, Lopez MM, Veligratli F, Calder F, Rees L. A comparison of arteriovenous fistulas and central venous lines for long-term chronic haemodialysis. Pediatr Nephrol. 2013;28(2):321–6.CrossRefPubMedGoogle Scholar
- 31.Blaney M, Shen V, Kerner JA, Jacobs BR, Gray S, Armfield J, Semba CP, CAPS Investigators. Alteplase for the treatment of central venous catheter occlusion in children: results of a prospective, open-label, single-arm study (The Cathflo Activase Pediatric Study). J Vasc Interv Radiol. 2006;17(11 Pt 1):1745–51.CrossRefPubMedGoogle Scholar
- 32.Bamgbola OF, del Rio M, Kaskel FJ, Flynn JT. Recombinant tissue plasminogen activator infusion for hemodialysis catheter clearance. Pediatr Nephrol. 2005;20:989–93.CrossRefPubMedGoogle Scholar
- 33.Gittins NS, Hunter-Blair YL, Matthews JN, Coulthard MG. Comparison of alteplase and heparin in maintaining the patency of paediatric central venous haemodialysis lines: a randomised controlled trial. Arch Dis Child. 2007;92:499–501.PubMedCentralCrossRefPubMedGoogle Scholar
- 34.Cachat F, Bardy D, Durussel C, Di Paolo E. Spurious hyperphosphatemia in a patient with alteplase-locked central venous catheter. Pediatr Nephrol. 2006;21:301–2.CrossRefPubMedGoogle Scholar
- 35.Ramage IJ, Bailie A, Tyerman KS, McColl JH, Pollard SG, Fitzpatrick MM. Vascular access survival in children and young adults receiving long-term hemodialysis. Am J Kidney Dis. 2005;45:708–14.CrossRefPubMedGoogle Scholar
- 36.Gradman WS, Lerner G, Mentser M, Rodriguez H, Kamil ES. Experience with autogenous arteriovenous access for hemodialysis in children and adolescents. Ann Vasc Surg. 2005;19:609–12.CrossRefPubMedGoogle Scholar
- 37.Dorsett-Martin WA. Review of microsurgery and arteriovenous fistulae for hemodialysis. Microsurgery. 2006;26:122–5.CrossRefPubMedGoogle Scholar
- 38.Manook M, Calder F. Practical aspects of arteriovenous fistula formation in the pediatric population. Pediatr Nephrol. 2013;28:885–93.CrossRefPubMedGoogle Scholar
- 39.Elsharawy MA, Moghazy KM. Impact of pre-operative venography on the planning and outcome of vascular access for hemodialysis patients. J Vasc Access. 2006;7:123–8.PubMedGoogle Scholar
- 40.Ponikvar R. Surgical salvage of thrombosed arteriovenous fistulas and grafts. Ther Apher Dial. 2005;9:245–9.CrossRefPubMedGoogle Scholar
- 41.Goldstein SL, Allsteadt A, Smith CM, Currier H. Proactive monitoring of pediatric hemodialysis vascular access: effects of ultrasound dilution on thrombosis rates. Kidney Int. 2002;62:272–5.CrossRefPubMedGoogle Scholar
- 42.Sheth RD, Brandt ML, Brewer ED, Nuchtern JG, Kale AS, Goldstein SL. Permanent hemodialysis vascular access survival in children and adolescents with end-stage renal disease. Kidney Int. 2002;62:1864–9.CrossRefPubMedGoogle Scholar
- 43.Maecken T, Grau T. Ultrasound imaging in vascular access. Crit Care Med. 2007;35(5 Suppl):S178–85.CrossRefPubMedGoogle Scholar
- 44.Rees L, Bockenhauer D, Webb N, Brogan P. Haemodialysis. In: Rees L, Bockenhauer D, Webb N, Brogan P, editors. Handbook of paediatric nephrology. Oxford University Press; 2011Google Scholar
- 45.Onder AM, Chandar J, Coakley S, Abitbol C, Montane B, Zilleruelo G. Predictors and outcome of catheter-related bacteremia in children on chronic hemodialysis. Pediatr Nephrol. 2006;21:1452–8.CrossRefPubMedGoogle Scholar
- 46.Onder AM, Chandar J, Saint-Vil M, Lopez-Mitnik G, Abitbol CL, Zilleruelo G. Catheter survival and comparison of catheter exchange methods in children on hemodialysis. Pediatr Nephrol. 2007;22:1355–61.CrossRefPubMedGoogle Scholar
- 47.Araya CE, Fennell RS, Neiberger RE, Dharnidharka VR. Hemodialysis catheter-related bacteremia in children: increasing antibiotic resistance and changing bacteriological profile. Am J Kidney Dis. 2007;50:119–23.CrossRefPubMedGoogle Scholar
- 48.Gorman G, Furth S, Hwang W, Parekh R, Astor B, Fivush B, Frankenfield D, Neu A. Clinical outcomes and dialysis adequacy in adolescent hemodialysis patients. Am J Kidney Dis. 2006;47:285–93.CrossRefPubMedGoogle Scholar
- 49.Juarez-Congelosi M, Orellana P, Goldstein SL. Normalized protein catabolic rate versus serum albumin as a nutrition status marker in pediatric patients receiving hemodialysis. J Ren Nutr. 2007;17:269–74.CrossRefPubMedGoogle Scholar
- 50.Good practice guidelines for renal dialysis/transplantation units: prevention and control of blood-borne virus infection. Department of Health, 2002Google Scholar
- 51.Srivaths PR, Wong C, Goldstein SL. Nutrition aspects in children receiving maintenance hemodialysis: impact on outcome. Pediatr Nephrol. 2009;24:951–7.PubMedCentralCrossRefPubMedGoogle Scholar
- 52.Rees L, Shaw V. Nutrition in children with CRF and on dialysis. Pediatr Nephrol. 2007;22:1689–702.PubMedCentralCrossRefPubMedGoogle Scholar
- 53.National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI). Clinical practice Guideline for Nutrition in Children with CKD: 2008 update. Am J Kidney Dis. 2009;53(3 Suppl 2):S11.CrossRefGoogle Scholar
- 54.Rees L. Management issues in children with renal disease. In: Hodson E, Eddy A, editors. BMJ evidence based publications. BMJ; 2008.Google Scholar
- 55.Verrina E, Caruso U, Calevo MG, Emma F, Sorino P, De Palo T, Lavoratti G, Turrini Dertenois L, Cassanello M, Cerone R, Perfumo F, Italian Registry of Pediatric Chronic Dialysis. Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis. Pediatr Nephrol. 2007;22:727–33.CrossRefPubMedGoogle Scholar
- 56.Waller S, Shroff R, Freemont S, Rees L. Bone histomorphometry in children prior to commencing renal replacement therapy. Pediatr Nephrol. 2008;23:1523–9.CrossRefPubMedGoogle Scholar
- 57.Moe S, Drüeke T, Cunningham J, Goodman W, Martin K, Olgaard K, Ott S, Sprague S, Lameire N, Eknoyan G, Kidney Disease: Improving Global Outcomes (KDIGO). Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2006;69:1945–53.CrossRefPubMedGoogle Scholar
- 58.Rees L. What parathyroid hormone levels should we aim for in children with stage 5 chronic kidney disease; what is the evidence? Pediatr Nephrol. 2008;23:179–84.PubMedCentralCrossRefPubMedGoogle Scholar
- 59.
- 60.Klaus G, Watson A, Edefonti A, Fischbach M, Rönnholm K, Schaefer F, Simkova E, Stefanidis CJ, Strazdins V, Vande Walle J, Schröder C, Zurowska A, Ekim M, European Podiatric Dialysis Working Group (EPDWG). Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines. Pediatr Nephrol. 2006;21:151–9.PubMedCentralCrossRefPubMedGoogle Scholar
- 61.Borzych D, Rees L, Ha IS, Chua A, Valles PG, Lipka M, IPPN. The bone and mineral disorder of children undergoing chronic peritoneal dialysis. Kidney Int. 2010;78(12):1295–304.CrossRefPubMedGoogle Scholar
- 62.Shroff RC, Donald AE, Hiorns MP, Watson A, Feather S, Milford D, Ellins EA, Storry C, Ridout D, Deanfield J, Rees L. Mineral metabolism and vascular damage in children on dialysis. J Am Soc Nephrol. 2007;18:2996–3003.CrossRefPubMedGoogle Scholar
- 63.Shroff R, Egerton M, Bridel M, Shah V, Donald AE, Cole TJ, Rees L. A bimodal association of vitamin D levels and vascular disease in children on dialysis. J Am Soc Nephrol. 2008;19(6):1239–46.PubMedCentralCrossRefPubMedGoogle Scholar
- 64.McDonald SP, Craig JC. Long-term survival of children with end-stage renal disease. N Engl J Med. 2004;350:2654–62.CrossRefPubMedGoogle Scholar
- 65.Foley RN, Parfrey PS, Sarnak MJ. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis. 1998;32:S112–9.CrossRefPubMedGoogle Scholar
- 66.Shroff R, Rees L, Trompeter R, Hutchinson C, Ledermann S. Long-term outcome of chronic dialysis in children. Pediatr Nephrol. 2005;21:257–64.CrossRefPubMedGoogle Scholar
- 67.Mitsnefes MM. Cardiovascular complications of pediatric chronic kidney disease. Pediatr Nephrol. 2008;23:27–39.PubMedCentralCrossRefPubMedGoogle Scholar