Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

CEA Gene Family

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_969-3

Synonyms

Definition

The carcinoembryonic antigen (CEA) gene family comprises 33 genes, 22 of which are expressed. All family members share similar structural features encompassing immunoglobulin (Ig) variable and/or constant domains and therefore constitute members of the large immunoglobulin superfamily. These proteins are either secreted or membrane bound. Several CEACAMs function as homophilic or heterophilic intercellular cell adhesion molecules. CEA, CEACAM1, CEACAM6, and CEACAM7 also play a significant role as regulators of tumor cell proliferation and differentiation and their overexpression (CEA and CEACAM6) or their downregulation (CEACAM1 and CEACAM7) contributes to progression of many epithelial cancers and immune dysfunctions.

Characteristics

The CEAgene family encodes a set of 22 genes and 11 pseudogenes clustered in a 1.8 Mb region on human chromosome 19q13.2...

Keywords

Insulin Clearance Upstream Stimulatory Factor CEACAM1 Expression Intercellular Cell Adhesion Molecule Bottle Brush 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Goodman Cancer Research CentreMcGill UniversityMontrealCanada