Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Adenovirus

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_91-2

Definition

Adenoviruses were originally isolated as etiologic agents for upper respiratory infections. Their name is derived from the initial observation that primary cell explants from human adenoids were found to degenerate secondary to the infection by an, at the time, unknown virus. According to the current official taxonomy, there are four adenovirus genera (Mastadenovirus, Atadenovirus, Aviadenovirus, and Siadenovirus), indicating that adenovirus is widely distributed in vertebrates. More than 50 human serotypes have been identified. The individual serotypes are distinguished by different parameters such as immunological properties, tumorigenicity, and DNA sequence. Some serotypes may cause more serious infectious diseases such as epidemic keratoconjunctivitis, gastroenteritis, or hemorrhagic cystitis. The adenoviral particle is composed of an outer icosahedral protein capsid with an inner linear double-stranded DNA genome of approximately 36 kilobases (kb) in size. There are 11...

Keywords

Adenoviral Vector Hemorrhagic Cystitis Helper Virus Adenoviral Serotypes Abortive Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Berk AJ (2007) Adenoviridae: the viruses and their replication. In: Fields BN, Knipe DM, Howley PM (eds) Fields virology, 3rd edn. Lippincott-Raven, Philadelphia/New York, pp 2355–2394Google Scholar
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  4. Wold WSM, Horwitz MS (2007) Adenoviruses. In: Fields virology, 5th edn. Lippincott-Raven, Philadelphia/New York, pp 2395–2436Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Division of Gene TherapyUniversity of UlmUlmGermany