Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

ABC Drug-Transporters

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_9-2

Synonyms

Definition

The adenosine triphosphate (ATP)-binding cassette (ABC) transporters form the largest family of transmembrane proteins that use ATP-derived energy to transport various substances over cell membranes. Primary-active transporters, driven by energy released from ATP by inherent ATPase activity, that export substrates from the cell against a chemical gradient. Based on the arrangement of the nucleotide-binding domain and the topology of its transmembrane domains, human ABC transporters are classified into seven distinct families (ABC-A to ABC-G), including ABCB1 (P-glycoprotein), ABCC1 (MRP1), ABCC2 (cMOAT, MRP2), ABCC4 (MRP4), and ABCG2 (ABCP, MXR, BCRP). Structural characteristics based on their Walker motif (ATP-binding domain) and their nucleotide-binding folds across the membrane are responsible for their classification into this superfamily. Their localization pattern over the body suggests that they have an...

Keywords

Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Adenosine Triphosphate Multidrug Resistance Protein Transporter Associate With Antigen Processing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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See Also

  1. (2012) Multidrug resistance. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2393. doi:10.1007/978-3-642-16483-5_3887Google Scholar
  2. (2012) Walker A Motif. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3941. doi:10.1007/978-3-642-16483-5_6228Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.German Cancer Research Center (DKFZ)HeidelbergGermany