The adenosine triphosphate (ATP)-binding cassette (ABC) transporters form the largest family of transmembrane proteins that use ATP-derived energy to transport various substances over cell membranes. Primary-active transporters, driven by energy released from ATP by inherent ATPase activity, that export substrates from the cell against a chemical gradient. Based on the arrangement of the nucleotide-binding domain and the topology of its transmembrane domains, human ABC transporters are classified into seven distinct families (ABC-A to ABC-G), including ABCB1 (P-glycoprotein), ABCC1 (MRP1), ABCC2 (cMOAT, MRP2), ABCC4 (MRP4), and ABCG2 (ABCP, MXR, BCRP). Structural characteristics based on their Walker motif (ATP-binding domain) and their nucleotide-binding folds across the membrane are responsible for their classification into this superfamily. Their localization pattern over the body suggests that they have an...
KeywordsCystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Adenosine Triphosphate Multidrug Resistance Protein Transporter Associate With Antigen Processing
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