Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cancer Vaccines

  • Malaya Bhattacharya-Chatterjee
  • Sunil K. Chatterjee
  • Asim Saha
  • Kenneth A. Foon
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_819-4

Definition

A vaccine should activate a unique lymphocyte (B and/or T cell) response, which has an immediate antitumor effect as well as memory response against future tumor challenge (Fig. 1). The primary role of a cancer vaccine is the treatment of cancer or prevention of recurrence in a patient with surgically resected cancer, rather than “prevention” of cancer in a person who has never had cancer. Therefore, cancer vaccines are not thought of in the traditional sense of vaccines that are used for infectious diseases. If the current cancer vaccines prove to be useful in the above respects, then they may have a future role in preventing cancer in persons who have never had cancer but are at high risk for a particular type of cancer.

Keywords

Tumor Cell Vaccine Active Specific Immunotherapy Allogeneic Tumor Cell Cancer Germline Antigen Polyvalent Melanoma Cell Vaccine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bhattacharya-Chatterjee M, Chatterjee SK, Foon KA (2002) Anti-idiotype antibody vaccine therapy for cancer. Expert Opin Biol Ther 2:869–881CrossRefPubMedGoogle Scholar
  2. Dalgleish AG, Whelan MA (2006) Cancer vaccines as a therapeutic modality: the long trek. Cancer Immunol Immunother 55:1025–1032CrossRefPubMedGoogle Scholar
  3. Emens LA (2006) Roadmap to a better therapeutic tumor vaccine. Int Rev Immunol 25:415–443CrossRefPubMedGoogle Scholar
  4. Nestle FO, Farkas A, Conrad C (2005) Dendritic-cell-based therapeutic vaccination against cancer. Curr Opin Immunol 17:163–169CrossRefPubMedGoogle Scholar
  5. Saha A, Chatterjee SK, Mohanty K et al (2003) Dendritic cell based vaccines for immunotherapy of cancer. Cancer Ther 1:299–314Google Scholar

See Also

  1. (2012) BCG. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 356. doi: 10.1007/978-3-642-16483-5_560Google Scholar
  2. (2012) FcR. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1386. doi: 10.1007/978-3-642-16483-5_2135Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Malaya Bhattacharya-Chatterjee
    • 1
  • Sunil K. Chatterjee
    • 1
  • Asim Saha
    • 1
  • Kenneth A. Foon
    • 2
  1. 1.University of Cincinnati and The Barrett Cancer CenterCincinnatiUSA
  2. 2.The Pittsburgh Cancer InstitutePittsburghUSA