Cancer Stem-Like Cells
Cancer stem(-like) cells are those cells that possess the capacity for self-renewal and for causing the heterogeneous lineages of cancer cells that comprise the tumor.
The definition follows a consensus at a workshop on cancer stem(-like) cells (CSC) organized by the American Association for Cancer Research (AACR). There is considerable debate and some controversy on the CSC concept, so that a consensus definition is required. The importance of the debate is proportional to its relevance to the change in our perception of cancer, intrinsic to the CSC paradigm, implying that not all cancer cells are equal but that only a small fraction of them is endowed with the properties of perpetuating the disease. This hierarchical model has not only important biological consequences but also relevant therapeutic implications, as we discuss in this essay.
The CSC paradigm fits in a model of cancer as a caricature of an organ that is already...
KeywordsAcute Myeloid Leukemia Chronic Myeloid Leukemia Cancer Stem Cell Side Population Blast Crisis
- Pellegatta S, Poliani PL, Corno D, Menghi F, Ghielmetti F, Suarez-Merino B, Caldera V, Nava S, Ravanini M, Facchetti F et al (2006) Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas. Cancer Res 66:10247–10252CrossRefPubMedGoogle Scholar