Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Calcium-Binding Proteins

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_778-2

Definition

Calcium-binding proteins are proteins that participate in calcium signaling pathways by binding to Ca2+. The most ubiquitous Ca2+-binding protein, found in all eukaryotic organisms including yeasts, is calmodulin. With their role in signal transduction, Ca2+-binding proteins contribute to all aspects of the cell’s functioning, from homeostasis to cancer.

Characteristics

Normal cell cycle division is a highly coordinated progression of molecular events that is subject to control mechanisms from both outside and inside the cell. Commitment to cell cycle initiation is made from outside and occurs as a response to extracellular signals such as growth factors. Inside the cell, control mechanisms exist to determine the timing of intracellular events such as nuclear and cytoplasmic cleavage. Under normal conditions, growth-regulating mechanisms endeavor to maintain homeostasis. Homeostasis within a cell is regulated by the balance between proliferation, growth arrest, and apoptosis...

Keywords

Human Breast Cancer Cell Line S100 Family Mouse Epidermal Cell Consensus Amino Acid Sequence Epidermal Differentiation Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Donato R (2003) Intracellular and extracellular roles of S100 proteins. Microsc Res Tech 60:540–551CrossRefPubMedGoogle Scholar
  2. Kretsinger RH, Tolbert D, Nakayama S et al (1991) The EF-hand, homologs and analogs. In: Heizmann CW (ed) Novel calcium-binding proteins: fundamentals and clinical implications. Springer, New York, pp 17–37CrossRefGoogle Scholar
  3. Pfyffer GE, Haemmerlit G, Heizmann CW (1984) Calcium-binding proteins in human carcinoma cell lines. Proc Natl Acad Sci U S A 81:6632–6636CrossRefPubMedPubMedCentralGoogle Scholar
  4. Pfyffer GE, Humbel B, Strauli P et al (1987) Calcium-binding proteins in carcinoma, neuroblastoma and glioma cell lines. Virchows Arch 412:135–144CrossRefGoogle Scholar

See Also

  1. (2012) EF-Hand Proteins. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1211. doi: 10.1007/978-3-642-16483-5_1819Google Scholar
  2. (2012) Proteins. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3099. doi: 10.1007/978-3-642-16483-5_4812Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Life ScienceHanyang UniversitySeoulSouth Korea