Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Exosomal miRNA

  • Shuai JiangEmail author
  • Wei Yan
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7227-1



Exosomes, shuttling from donor cells to recipient cells, are cell-derived extracellular vesicles (EV) with 30–100 nm in diameter and dish- or classic cup-shaped morphology. Exosomes transport bioactive cargo carrying selective proteins, lipids, DNA, messenger RNAs (mRNAs), and small and large noncoding RNAs such as microRNAs (miRNAs). miRNA embedded in exosomes is termed as exosomal miRNA. Exosomal miRNAs regulate diverse biological processes in recipient cells.


Biogenesis of Exosomes and Exosomal miRNA Packaging

Exosomes play a fundamental role in cell-cell communication and have been found in various cell types, especially in tumor cells. Cluster of differentiation (CD) 63, CD81, heat shock protein (HSP) 70, Alix (ALG-2-interacting protein X), and TSG101 (tumor susceptibility gene 101) serve as exosomal marker proteins. Exosomes are derived from the multivesicular bodies (MVBs), which are also known as...


Recipient Cell Extracellular Vesicle Exosome Secretion Metastatic Breast Cancer Cell Line Inhibit Breast Cancer Cell Growth 
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See Also

  1. (2012) P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2747. doi:10.1007/978-3-642-16483-5_4331Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Biology and Biological EngineeringCalifornia Institute of TechnologyPasadenaUSA
  2. 2.Department of Cancer BiologyBeckman Research Institute of City of HopeDuarteUSA