Latency-Associated Nuclear Antigen (LANA)
The latency-associated nuclear antigen (LANA) is one of the major latent proteins of the Kaposi’s sarcoma herpesvirus (KSHV) or human herpesvirus 8 (HHV8). It was first discovered as a serologic antigen, and since then it is a gold standard detection tool for KSHV infection. KSHV is associated with Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman disease (MCD), and LANA is detected in any form of KS. In KSHV-infected cells LANA is detected as a dot-like staining by immunohistochemistry or immunofluorescence.
LANA is encoded by KSHV ORF73, and it is mainly expressed from a polycistronic transcript (LT1). LT1 also includes other latent proteins as v-cyclin, a viral homologue of the cellular cyclin D, and the viral homologue of the cellular FLICE-like inhibitory protein (v-FLIP). These last two proteins encoded by ORF72 and ORF71/K13,...
KeywordsOrigin Recognition Complex Primary Effusion Lymphoma Lytic Replication Multicentric Castleman Disease Major Latent Promoter
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