Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Ca2+ Homeostasis

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7208-1

Definition

Ca2+ homeostasis is the dynamic equilibrium of Ca2+ ion concentration in the body or in the cell (“cellular Ca2+ homeostasis”).

Characteristics

Even if 99 % of the Ca2+ ions of the body are trapped in the bones and could be considered as stable, Ca2+ homeostasis refers to the control of the free Ca2+ ion concentrations at the extracellular (“[Ca2+]ex”) and the intracellular (“[Ca2+]i”) levels.

Control of [Ca2+]ex is important because Ca2+ ions stabilize numerous ionic channels like the voltage-gated ones: thus a decrease of [Ca2+]ex could induce spontaneous contraction of muscles, implying that [Ca2+]ex must be tightly controlled in the blood. This is mainly done by parathyroid hormone that controls the uptake of Ca2+ ions by the gusts, the release by the bones, and the reabsorption by the kidneys.

Cellular Ca2+ Homeostasis

At the cellular level, [Ca2+]i is an equilibrium between the Ca2+ ion concentration of the different compartments, mainly the cytosol ([Ca2+]cyt),...

Keywords

Cell Stimulation Internal Store Plasma Membrane Channel ORAI1 Channel Numerous Cancer Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

  1. (2012) Ca 2+ aTPase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin, p 577. doi:10.1007/978-3-642-16483-5_763Google Scholar
  2. (2012) Ca 2+ -release channels. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 577. doi:10.1007/978-3-642-16483-5_764Google Scholar
  3. (2012) Calcineurin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 584. doi:10.1007/978-3-642-16483-5_775Google Scholar
  4. (2012) Cyclosporin A. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1036. doi:10.1007/978-3-642-16483-5_1440Google Scholar
  5. (2012) Inositol 1,4,5-trisphosphate. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1870. doi:10.1007/978-3-642-16483-5_3071Google Scholar
  6. (2012) T lymphocyte. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3600. doi:10.1007/978-3-642-16483-5_5654Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Signalisation Calcique et Interactions Cellulaires dans le FoieINSERM UMR-S 1174, Université Paris-Sud 11OrsayFrance