Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Artemisinin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7201-1

Synonyms

Definition

Artemisinin, a natural product (Fig. 1) isolated from the sweet wormwood Artemisia annua L, is a sesquiterpene lactone. Artemisinin has molecular formula of C 15H 22O 5 (MW = 282.34). The structure of artemisinin contains fused 6- and 7-membered rings with a peroxide bridge (endoperoxide). Pure artemisinin is a white and crystalline powder that melts at 152–157 °C. Artemisinin is soluble in organic solvents but almost insoluble in water.

Keywords

Pancreatic Cancer Endometrial Cancer Sesquiterpene Lactone Reactive Oxidative Species Artemisinic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Ades V (2011) Safety, pharmacokinetics and efficacy of artemisinins in pregnancy. Infect Dis Rep 3:e8PubMedCentralCrossRefPubMedGoogle Scholar
  2. Corsello MA, Garg NK (2015) Synthetic chemistry fuels interdisciplinary approaches to the production of artemisinin. Nat Prod Rep 32:359–366Google Scholar
  3. Lai H, Singh NP, Sasaki T (2013) Development of artemisinin compounds for cancer treatment. Invest New Drugs 31:230–246CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Henry Lai
    • 1
  • Narendra P. Singh
    • 1
  • Tomikazu Sasaki
    • 2
  1. 1.Departments of BioengineeringUniversity of WashingtonSeattleUSA
  2. 2.Department of ChemistryUniversity of WashingtonSeattleUSA