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Encyclopedia of Cancer pp 1–5Cite as

Pancreatic Cancer Development and Regeneration

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Definition

Understanding of progenitor cells and processes for embryonic development of the pancreas and regeneration holds the key for solving mysteries of pancreatic cancer development since many of these pathways are found to be activated in pancreatic tumors. It can also provide clues to regenerate the pancreas following injuries arising from diabetes, pancreatitis, and surgical insult.

Characteristics

Functional Morphology of the Pancreas

On average daily, the pancreas secretes 1,200 ml of pancreatic juice comprising of digestive enzymes necessary for digestion of food and hormones important for blood glucose homeostasis. The pancreas as a glandular organ comprises digestive enzyme-secreting exocrine cells (acinar cells), hormone-secreting endocrine cells (islets of Langerhans), and epithelial duct cells forming a lumen which carries the pancreatic secretions to the common bile duct and intestine.

Endocrine Component

Constituting about 1 % of the adult human pancreas, more than a...

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References

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Author information

Authors and Affiliations

  1. Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Sonal Gupta

Authors
  1. Sonal Gupta
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Corresponding author

Correspondence to Sonal Gupta .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2014 Springer-Verlag Berlin Heidelberg

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Gupta, S. (2014). Pancreatic Cancer Development and Regeneration. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7186-3

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_7186-3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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