Leukemia Stem Cells
Leukemia stem cells (LSCs) are the progenitors (or precursors) of all malignant blood cell lineages. They were first described less than 20 years ago in mouse xenograft models of acute myeloid leukemia (AML). The LSCs are characterized by extensive self-renewal and limited capacity to differentiate into committed progenies that are termed leukemic blasts. As the precursors of all malignant hematopoiesis, they parallel normal hematopoietic stem cells (HSCs). LSCs initiate and sustain leukemia, and residual LSCs after therapy cause relapse of the disease. Targeting LSCs has implications for eradication of leukemia.
Surface Phenotype of LSCs
LSCs were initially characterized by Dick and co-workers, who demonstrated that the CD34+CD38−bone marrow or blood cell fraction was highly enriched with an abnormal cell type that has an immunophenotypic profile similar to that of normal HSCs. These cells...
KeywordsAcute Myeloid Leukemia Chronic Myeloid Leukemia Acute Myeloid Leukemia Patient Acute Myeloid Leukemia Cell Gemtuzumab Ozogamicin
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