Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Methyltransferases

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7078-7

Synonyms

Definition

Methyltransferases (MTases) are a family of enzymes that catalyze the transfer of a methyl group from a donor to an acceptor. Methyltransferases are found in both prokaryotes and eukaryotes; however, their structure and function are different. Based on the substrate for methylation, the two well-known types of methyltransferases in vertebrates are DNA methyltransferase (DNMTases) and histone methyltransferase (HMTases). Besides the DNMTases and HMTases, there is another class of MTases that catalyzes the transfer of methyl group to the 5-prime-terminal guanosine of pre-mRNA, known as RNA MTases.

Characteristics

DNMTases

Depending on bases and the position of its carbon in DNA on which the DNMTases catalyze the transfer of methyl group, DNMTases can be divided into three different groups:
  • N-6 adenine-specific DNA methylase (A-MTase): This class of enzymes known as m6A methyltransferases, specifically methylates the amino group at the C-6 position of...

Keywords

Histone Methyltransferases Early Embryogenesis Stage Host Restriction Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bestor TH (2000) The DNA methyltransferases of mammals. Hum Mol Genet 9:2395–2402CrossRefPubMedGoogle Scholar
  2. Bourc’his D, Xu G, Lin C, Bollman B, Bestor T (2001) DNMT3L and the establishment of maternal genomic imprints. Science 294:2536–2539CrossRefPubMedGoogle Scholar
  3. Esteller M (2008) Epigenetics in cancer. N Engl J Med 358:1148–1159CrossRefPubMedGoogle Scholar
  4. Jenuwein T, Allis CD (2001) Translating the histone code. Science 293:1074–1080CrossRefPubMedGoogle Scholar
  5. Robertson KD (2005) DNA methylation and human disease. Nat Rev Genet 6:597–610CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.The Institute of Environmental and Human Health (TIEHH)Texas Tech UniversityLubbockUSA