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B-Raf Signaling

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 39 Accesses

Synonyms

BRAF; B-raf-1; BRAF1; EC 2.7.11.1; MGC126806; MGC138284; p94; RAFB1; v-raf murine sarcoma viral oncogene homolog B1; c-Rmil

Definition

B-Raf signaling comprises the activation of the proto-oncogene product B-Raf and its downstream effectors and represents a key regulatory step in the activation of the canonical MAP kinase pathway by various extracellular stimuli and oncogene products such as Ras and activated receptor tyrosine kinases (RTKs) like NTRK and RET. Aberrant B-Raf activity as a result of somatic mutations is observed in 8 % of human cancers.

Characteristics

Physiological Aspects of B-Raf Signaling

B-Raf is a member of the Raf kinasefamily and represents an important component of the Ras/Raf/MEK/ERK MAP kinase signal transduction pathway, which plays a pivotal role in growth control and differentiation. Dysregulation of this pathway is observed in about 30 % of human tumors and represents an established mechanism for tumorigenesis. In their role as gatekeepers of...

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References

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See also

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  • (2012) Angiogenic switch. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 186. doi:10.1007/978-3-642-16483-5_277

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Author information

Authors and Affiliations

  1. Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University, Freiburg, Germany

    Tilman Brummer

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  1. Tilman Brummer
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Correspondence to Tilman Brummer .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Brummer, T. (2014). B-Raf Signaling. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_704-4

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_704-4

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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